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Whole Genome Sequencing | WGS Test | Henotic Diagnostics
Whole Genome Sequencing: Fast & Precise WGS Test
Advanced Clinical Whole Genome Sequencing Experts
First of all, Whole Genome Sequencing (WGS) is the ultimate genetic diagnostic test, reading all 3 billion base pairs across the entire human genome. Essentially, Next-Generation Sequencing (NGS) profiles both protein-coding exonic regions (~2%) and non-coding intronic regulatory sequences (~98%). As a result, medical geneticists solve uncharacterized genetic conditions that remain invisible on standard exome panels.
Book your WGS Test at Henotic Diagnostics for absolute genomic clarity. Furthermore, our accredited diagnostic facility operates 24/7 to provide seamless sample collection.
To begin with, WGS Test (WGS) is the most comprehensive diagnostic tool available in modern genomic medicine. At the same time, experts at Henotic Diagnostics deploy ultra-high-throughput Next-Generation Sequencing to decode your complete 3 billion base pair DNA sequence.
What Does Whole Genome Sequencing Evaluate?
Specifically, WGS evaluates single nucleotide variants (SNVs), copy number variants (CNVs), structural rearrangements, deep intronic splice mutations, promoter region defects, and mitochondrial DNA variants. Consequently, clinical geneticists identify root causes of undiagnosed rare pediatric conditions. Furthermore, high-depth 30x sequencing eliminates blind spots inherent in targeted panels. As a result, physicians formulate tailored therapeutic strategies. In fact, to review clinical research standards, consult the NIH NHGRI WGS Test resource.
In general, WGS is an all-inclusive genomic decoding technology. Essentially, while Whole Exome Sequencing reads only the 1-2% of DNA that encodes proteins, WGS reads 100% of the nuclear and mitochondrial DNA. Specifically, powerful bioinformatic supercomputers align billions of short or long reads against human reference genomes. Therefore, variant calling software pinpoints pathogenic mutations hidden deep inside non-coding intronic sequences. Additionally, this single test provides a lifetime genomic baseline.
Additionally, high-throughput NGS platforms process full human genomes at uniform 30x depth
What Does Whole Genome Sequencing Check?
Overall, the test provides complete structural, functional, and non-coding genomic analysis:
Key Genomic Variants & Regions Examined
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3 Billion Base Pair Coverage: First, it reads all 23 pairs of autosomes, sex chromosomes (X/Y), and mitochondrial DNA.
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Non-Coding Intronic & Promoter Mutations: Second, it uncovers deep intronic splice variants that break mRNA transcript stability.
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Structural Variants & Copy Number Changes: In addition, it detects large chromosomal duplications, deletions, and inversions.
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Pharmacogenomics & Carrier Screening: Finally, it maps drug metabolism genes (CYP450) and recessive hereditary carrier risks.
In addition, bioinformatic software pipelines filter 3 billion base pairs to isolate clinically actionable mutations
When Is Whole Genome Sequencing Recommended?
For example, clinical geneticists and specialists recommend WGS Test for complex medical scenarios. In particular, doctors order WGS for patients with unresolved rare diseases after negative exome sequencing or microarray tests. Moreover, it is recommended for complex neurodevelopmental syndromes, refractory pediatric epilepsy, and rare metabolic disorders. In addition, individuals seeking comprehensive proactive genomic health profiling opt for WGS.
Moreover, expert genetic counseling translates full-genome sequencing reports into personalized medical management
Clinical Advantage of WGS in Unsolved Genetic Odysseys
Why WGS Resolves Cases Missed by Whole Exome Testing
Ideally, patients should consider WGS if Whole Exome Sequencing (WES) yields negative results despite clear hereditary symptoms. In addition, if non-coding promoter mutations or structural break-points cause disease, WGS is the only test that detects them. Indeed, full genome sequencing provides the ultimate diagnostic clarity.
Whole Genome Sequencing Cost Guide
Genomic Diagnostic Service
Approximate Cost (₹)
Whole Genome Sequencing (30x Clinical Depth)
First, standard WGS test pricing is ₹45,000 – ₹55,000.
In addition, Trio WES test costs ₹35,000 – ₹55,000.
Post-Test Genetic Counseling Session
Finally, expert genetic consultation fee is ₹1,500 – ₹2,500.
Comparison: Whole Genome Sequencing vs. Whole Exome Sequencing (WES)
On one hand, Whole Exome Sequencing captures only the 1-2% of coding DNA, whereas WGS Test reads 100% of all 3 billion base pairs including non-coding introns. Consequently, WGS detects structural rearrangements and intronic variants missed by WES.
Feature
Whole Genome Sequencing (WGS)
Whole Exome Sequencing (WES)
Genome Coverage
First, WGS reads 100% of 3 billion base pairs (coding + non-coding).
However, WES reads only ~1-2% coding exome regions.
Non-Coding Intron Detection
Second, WGS detects deep intronic splice and promoter mutations.
In contrast, WES completely misses non-coding intronic mutations.
Structural & CNV Sensitivity
In addition, uniform coverage enables high structural variant sensitivity.
MBBS, MD (Radiodiagnosis) · 15+ Years Clinical Experience
Furthermore, your Whole Genome Sequencing data is evaluated and reported by senior clinical geneticists and bioinformaticians following ACMG guidelines. Consequently, detailed reports provide treating physicians with definitive evidence for patient care.
Real feedback from patients who completed Whole Genome Sequencing with us.
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“Whole Genome Sequencing at Henotic Diagnostics finally solved my daughter’s rare genetic disorder after exome testing missed the intronic mutation. Furthermore, the genetic counseling was life-changing.”
– Dr. Manish P.
Verified Patient Review
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“Smooth blood collection at home. In addition, receiving our raw FASTQ and BAM digital files alongside the ACMG report was fantastic.”
– Swati R.
Verified Patient Review
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“Transparent pricing and NABL accredited facility. Dr. Pratibha Patil’s team delivers gold standard molecular diagnostic care.”
If you require a high precision Whole Genome Sequencing test for comprehensive genetic evaluation, do not delay. Call to schedule your sample collection.
Henotic Diagnostics
Second floor, Millennium Empire, Business Park, Plot No 47, D Mart Rd, Sector 15
You can book your Whole Genome Sequencing appointment at our Navi Mumbai center through multiple convenient channels: call us directly at 088793 27184, send a WhatsApp message for instant booking, or use the online booking form on our website. Walk-in appointments are also welcome based on slot availability. We recommend advance booking to ensure zero wait times.
Yes, Henotic Diagnostics Navi Mumbai is empanelled with all major insurance companies and TPAs (Third Party Administrators) including Star Health, ICICI Lombard, New India Assurance, HDFC Ergo, Max Bupa, Bajaj Allianz, and many more. We offer cashless processing for Whole Genome Sequencing where applicable. Please carry your insurance card and a valid ID for seamless processing.
At Henotic Diagnostics Navi Mumbai, most Whole Genome Sequencing reports are delivered within 2-6 hours for routine tests. Critical and urgent reports are expedited on a priority basis. All reports are delivered digitally via WhatsApp, email, and our secure online patient portal. Hard copies are also available at the center upon request. You will receive an SMS/WhatsApp notification the moment your report is ready.
Henotic Diagnostics Navi Mumbai operates 24 hours a day, 7 days a week, including Sundays and public holidays. This means you can schedule your Whole Genome Sequencing at a time that is most convenient for you — early morning, late evening, or even overnight for emergency requirements. Our radiology and pathology departments maintain round-the-clock availability.
Yes, Henotic Diagnostics Navi Mumbai is fully accredited by NABL (National Accreditation Board for Testing and Calibration Laboratories) and ISO 9001:2015 certified. Our radiology equipment also complies with AERB (Atomic Energy Regulatory Board) safety standards. These accreditations ensure that every Whole Genome Sequencing performed at our facility meets the highest national and international quality benchmarks for accuracy, safety, and reliability.
