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First of all, Chromosomal Microarray (CMA) is the gold-standard molecular cytogenetic test recommended for detecting submicroscopic chromosomal gains and losses. Essentially, using high-density Single Nucleotide Polymorphism (SNP) array technology across 750,000+ probes, CMA evaluates copy number variations (CNVs), microdeletions, microduplications, and loss of heterozygosity down to 10 kilobases with 99.9% precision.
Furthermore, book your Single Nucleotide Polymorphism Array (SNP Array) at Henotic Diagnostics for authoritative diagnostic clarity. In addition, our accredited genomic laboratory operates 24/7 with convenient home sample collection services.
Moreover, Prenatal & Pediatric Diagnostic Gold Standard
Finally, ISO Certified
Chromosomal Microarray Test: Overview
To begin with, Single Nucleotide Polymorphism Array (SNP Array) is an advanced molecular genomic technology designed to scan the entire human genome for chromosomal imbalance. At the same time, experts at Henotic Diagnostics process patient DNA on high-density microfluidic array chips to identify structural microdeletions and microduplications.
Specifically, Single Nucleotide Polymorphism Array (SNP Array) analyzes 23 pairs of human chromosomes for submicroscopic gain or loss of genetic material. Consequently, bioinformatic algorithms detect microdeletion syndromes (e.g. DiGeorge, Williams, Prader-Willi) and microduplications that escape conventional G-banded karyotyping. Furthermore, SNP probes map Absence of Heterozygosity (AOH) linked to uniparental disomy and consanguinity. As a result, pediatricians and obstetricians obtain conclusive genetic diagnoses. In fact, to review chromosomal structure facts, consult the NIH NHGRI Chromosomes Fact Sheet.
Furthermore, Advanced Molecular Cytogenetics providing clear microdeletion and CNV insights.
What is Chromosomal Microarray?
In general, while traditional karyotyping resolves large chromosomal alterations (>5-10 megabases), Single Nucleotide Polymorphism Array (SNP Array) achieves submicroscopic resolution down to 10-50 kilobases (100 times higher resolution). Essentially, patient DNA and reference controls are hybridized onto array chips containing hundreds of thousands of genomic probes. Therefore, automated scanners calculate signal intensity ratios to pinpoint microscopic deletions and duplications. Additionally, to read about copy number variation genetics, examine the Nature Genetics journal.
Additionally, high-resolution SNP microarray scanners analyze 750,000+ probes with 99.9% copy number accuracy
Submicroscopic Microduplications: Second, uncovers duplicated chromosomal regions causing developmental delay and structural anomalies.
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Absence of Heterozygosity (AOH): In addition, detects uniparental disomy (UPD) and identity-by-descent regions. Review the ClinVar NCBI variant database.
In addition, cytogenetic bioinformatic software displays log2 copy number ratio shifts and SNP allele peaks
When Is Chromosomal Microarray Recommended?
For example, pediatricians, pediatric neurologists, and obstetricians order Chromosomal Microarray for first-line genetic evaluation. In particular, testing is recommended for children with unexplained developmental delay, intellectual disability, autism spectrum disorder (ASD), and congenital anomalies. Moreover, in prenatal care, CMA is the primary test for fetal structural malformations detected on ultrasound or abnormal NIPT screens. In addition, to review ACMG diagnostic standards, examine the ACMG Medical Genetics guidelines.
Clinical Superiority: First-Line CMA vs. Traditional G-Banded Karyotyping
Why Chromosomal Microarray Replaces Karyotype for Developmental Delay
Ideally, pediatricians recommend Chromosomal Microarray (CMA) as the first-tier diagnostic test because conventional karyotyping misses over 80% of pathogenic microdeletions and microduplications. In addition, CMA yields a diagnostic yield of 15-20% compared to only 3% for karyotyping in developmental disorders. Indeed, to review global rare genetic disease facts, consult the WHO Rare Genetic Disease & Health Fact Sheet.
Chromosomal Microarray Cost Guide
Clinical CMA Service
Approximate Cost (₹)
Standard CMA 750k SNP Array Panel
First, standard CMA 750k pricing is ₹12,000 – ₹16,000.
High-Density CMA 2.6M Probe Array Panel
Second, ultra-high density CMA 2.6M costs ₹18,000 – ₹22,000.
In addition, specialized sample handling is complimentary.
Clinical Genetic Counseling Consultation
Finally, expert genetic counseling fee is ₹1,000 – ₹1,500.
Comparison: Chromosomal Microarray (CMA) vs. G-Banded Karyotype vs. WES
On one hand, G-banded karyotyping visualizes whole chromosomes under microscopes, whereas Chromosomal Microarray (CMA) measures submicroscopic copy number variations, and Whole Exome Sequencing (WES) identifies single nucleotide gene mutations. Consequently, selecting the proper genetic test ensures efficient diagnostic resolution. In fact, review the PubMed Clinical Chromosomal Microarray Review.
Feature
Chromosomal Microarray (CMA)
G-Banded Karyotyping
Genomic Resolution
First, submicroscopic 10-50 kb resolution.
However, macro-level 5-10 Mb resolution.
Diagnostic Yield (Developmental Delay)
Second, high yield of 15% – 20%.
In contrast, low yield of ~3%.
Balanced Translocation Detection
In addition, misses balanced translocations.
Meanwhile, detects balanced translocations.
Cell Culture Requirement
Finally, no live cell culture needed.
Likewise, requires viable metaphase cells.
Frequently Asked Questions
What is a Chromosomal Microarray test used for?▼
Chromosomal Microarray detects chromosomal copy-number changes. Therefore, Henotic Diagnostics may recommend CMA for developmental delay, intellectual disability, congenital anomalies, or selected prenatal findings.
What does CMA detect that karyotyping cannot?▼
CMA detects many smaller microdeletions and microduplications that standard karyotyping may miss. Therefore, it provides higher-resolution copy-number analysis.
When is prenatal CMA recommended?▼
Prenatal CMA may be recommended when fetal structural abnormalities are identified or when clinically indicated after genetic counseling. Therefore, the decision should be made with the treating obstetrician or genetics professional.
Can CMA detect single-gene disorders?▼
Generally, no. CMA primarily detects copy-number changes, whereas single-gene disorders usually require sequencing-based tests such as WES or targeted gene testing.
How long until I receive diagnostic Chromosomal Microarray results?▼
Fortunately, detailed clinical bioinformatic CMA reports are delivered within 7 to 10 business days.
What is the cost of Chromosomal Microarray?▼
Overall, high-precision Chromosomal Microarray ranges from ₹12,000 to ₹22,000 all-inclusive.
Quick Appointment Booking
Schedule your Chromosomal Microarray with accredited genomic experts.
MBBS, MD (Genetics) · 15+ Years Clinical Experience
Furthermore, your Chromosomal Microarray data is evaluated by accredited molecular cytogeneticists and geneticists. Consequently, comprehensive reports empower pediatricians and obstetricians with clear microdeletion and CNV insights.
Our Accreditations & Quality Standards
Certified excellence ensuring SNP microarray precision, bioinformatic CNV interpretation accuracy, and patient privacy.
What Our Patients Say
Real feedback from patients who completed Chromosomal Microarray testing with us.
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“Chromosomal Microarray identified a 22q11.2 microdeletion in my son that explaining his developmental delay. Furthermore, targeted therapies were started promptly!”
– Arvind S.
Verified Patient Review
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“Prompt amniotic fluid CMA testing after an abnormal prenatal scan gave us complete peace of mind. In addition, the genetic consultation was invaluable.”
– Kavita R.
Verified Patient Review
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“Outstanding NABL accredited molecular cytogenetics lab. Henotic Diagnostics is our premier referral center for pediatric CMA testing.”
If you require Chromosomal Microarray for microdeletion, developmental delay, or prenatal evaluation, do not delay. Call to schedule your sample collection.
Henotic Diagnostics
Second floor, Millennium Empire, Business Park, Plot No 47, D Mart Rd, Sector 15, Kharghar, Navi Mumbai, Panvel, Maharashtra 410210
You can book your Chromosomal Microarray appointment at our Navi Mumbai center through multiple convenient channels: call us directly at 088793 27184, send a WhatsApp message for instant booking, or use the online booking form on our website. Walk-in appointments are also welcome based on slot availability. We recommend advance booking to ensure zero wait times.
Yes, Henotic Diagnostics Navi Mumbai is empanelled with all major insurance companies and TPAs (Third Party Administrators) including Star Health, ICICI Lombard, New India Assurance, HDFC Ergo, Max Bupa, Bajaj Allianz, and many more. We offer cashless processing for Chromosomal Microarray where applicable. Please carry your insurance card and a valid ID for seamless processing.
At Henotic Diagnostics Navi Mumbai, most Chromosomal Microarray reports are delivered within 2-6 hours for routine tests. Critical and urgent reports are expedited on a priority basis. All reports are delivered digitally via WhatsApp, email, and our secure online patient portal. Hard copies are also available at the center upon request. You will receive an SMS/WhatsApp notification the moment your report is ready.
Henotic Diagnostics Navi Mumbai operates 24 hours a day, 7 days a week, including Sundays and public holidays. This means you can schedule your Chromosomal Microarray at a time that is most convenient for you — early morning, late evening, or even overnight for emergency requirements. Our radiology and pathology departments maintain round-the-clock availability.
Yes, Henotic Diagnostics Navi Mumbai is fully accredited by NABL (National Accreditation Board for Testing and Calibration Laboratories) and ISO 9001:2015 certified. Our radiology equipment also complies with AERB (Atomic Energy Regulatory Board) safety standards. These accreditations ensure that every Chromosomal Microarray performed at our facility meets the highest national and international quality benchmarks for accuracy, safety, and reliability.
