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First of all, Transcriptome Sequencing (RNA-Seq) is the premier molecular diagnostic method that profiles total cellular RNA expression in real time. Essentially, high-throughput Next-Generation Sequencing measures active gene transcription, novel oncogenic gene fusions, and alternative splice variants with 99.9% precision. Consequently, oncologists and clinical geneticists identify actionable therapeutic targets that DNA-only sequencing misses.
Furthermore, book your Gene Expression Profiling at Henotic Diagnostics for comprehensive diagnostic precision. In addition, our accredited genomic laboratory operates 24/7 with dedicated sample logistics support.
To begin with, the Transcriptome represents the complete set of RNA transcripts produced by the genome at a specific physiological moment. At the same time, experts at Henotic Diagnostics convert cellular RNA into complementary DNA (cDNA) libraries for high-depth Next-Generation Sequencing.
What Does Transcriptome Sequencing Evaluate?
Specifically, Gene Expression Profiling quantifies messenger RNA (mRNA) levels to determine which genes are actively turned on or suppressed. Consequently, bioinformatic pipelines identify oncogenic driver gene fusions (NTRK, RET, ALK, ROS1) and aberrant splicing isoforms. Furthermore, high-depth RNA-Seq maps non-coding RNA regulatory networks. As a result, oncologists select precise targeted biological therapies. In fact, to review foundational transcriptome concepts, consult the NIH NHGRI Transcriptome Fact Sheet.
In general, while DNA sequencing reveals static genetic blueprints, Gene Expression Profiling (RNA-Seq) captures dynamic cellular activity. Essentially, RNA is extracted, purified, depleted of ribosomal RNA, and sequenced to generate millions of short sequence reads. Therefore, bioinformatic software maps reads to reference genomes to quantify differential gene expression. Additionally, to read about technological advances, examine the Nature Reviews Genetics RNA-Seq journal.
Additionally, high-throughput NGS sequencers sequence total cellular RNA with 99.9% diagnostic accuracy
In addition, bioinformatic software maps gene fusion junctions, RNA expression heatmaps, and splice graphs
When Is Transcriptome Sequencing Recommended?
For example, medical oncologists and hematologists order Transcriptome Sequencing for advanced or refractory cancers to uncover rare gene fusions. In particular, testing is recommended for lung adenocarcinoma, sarcomas, pediatric tumors, and hematologic malignancies. Moreover, it is used in rare genetic disease research when DNA sequencing yields uninformative results. In addition, to review precision oncology standards, examine the NCI Precision Medicine in Cancer guide.
Moreover, expert clinical consultation translates RNA fusion data into targeted kinase inhibitor therapies
Clinical Advantage: RNA-Seq Fusion Detection vs. DNA Panel Limitations
Why RNA-Seq Identifies Fusions Hidden in Long Intronic Regions
Ideally, oncologists should order Transcriptome Sequencing (RNA-Seq) because genomic DNA panels often miss gene fusions occurring across vast, repetitive intronic regions. In addition, RNA sequencing directly captures expressed chimeric mRNA transcripts without intron interference. Indeed, to review global cancer diagnostic facts, consult the WHO Cancer & Diagnostics Fact Sheet.
Transcriptome Sequencing Cost Guide
Clinical RNA Sequencing Service
Approximate Cost (₹)
Targeted RNA Gene Fusion Panel
First, targeted oncology RNA fusion pricing is ₹35,000 – ₹45,000.
In addition, PaxGene / RNA-later kit delivery is complimentary.
Clinical Bioinformatic Report Consultation
Finally, expert consultation fee is ₹1,000 – ₹1,500.
Comparison: Whole Transcriptome (RNA-Seq) vs. Whole Exome (WES)
On one hand, Whole Exome Sequencing (WES) analyzes DNA mutations in coding exons, whereas Whole Transcriptome Sequencing (RNA-Seq) measures active RNA transcription levels and expressed fusion transcripts. Consequently, combining DNA WES with RNA-Seq provides complete diagnostic precision. In fact, review the PubMed Clinical RNA Sequencing Review.
MBBS, MD (Transcriptomics) · 15+ Years Clinical Experience
Furthermore, your Transcriptome Sequencing data is interpreted by accredited molecular geneticists and bioinformaticians. Consequently, comprehensive reports empower oncologists with actionable RNA expression and fusion target insights.
Real feedback from patients who completed Transcriptome Sequencing with us.
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“Transcriptome Sequencing discovered a rare NTRK fusion in my tumor block that DNA sequencing missed. Furthermore, targeted therapy shrank the tumor within weeks!”
– Devendra M.
Verified Patient Review
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“The specialized PaxGene blood tube delivery and sample handling were flawless. In addition, the genetic counselor explained the RNA report clearly.”
If you require Transcriptome Sequencing for RNA-Seq gene expression or oncogenic fusion detection, do not delay. Call to schedule your sample collection.
Henotic Diagnostics
Second floor, Millennium Empire, Business Park, Plot No 47, D Mart Rd, Sector 15, Kharghar, Navi Mumbai, Panvel, Maharashtra 410210
You can book your Transcriptome Sequencing appointment at our Navi Mumbai center through multiple convenient channels: call us directly at 088793 27184, send a WhatsApp message for instant booking, or use the online booking form on our website. Walk-in appointments are also welcome based on slot availability. We recommend advance booking to ensure zero wait times.
Yes, Henotic Diagnostics Navi Mumbai is empanelled with all major insurance companies and TPAs (Third Party Administrators) including Star Health, ICICI Lombard, New India Assurance, HDFC Ergo, Max Bupa, Bajaj Allianz, and many more. We offer cashless processing for Transcriptome Sequencing where applicable. Please carry your insurance card and a valid ID for seamless processing.
At Henotic Diagnostics Navi Mumbai, most Transcriptome Sequencing reports are delivered within 2-6 hours for routine tests. Critical and urgent reports are expedited on a priority basis. All reports are delivered digitally via WhatsApp, email, and our secure online patient portal. Hard copies are also available at the center upon request. You will receive an SMS/WhatsApp notification the moment your report is ready.
Henotic Diagnostics Navi Mumbai operates 24 hours a day, 7 days a week, including Sundays and public holidays. This means you can schedule your Transcriptome Sequencing at a time that is most convenient for you — early morning, late evening, or even overnight for emergency requirements. Our radiology and pathology departments maintain round-the-clock availability.
Yes, Henotic Diagnostics Navi Mumbai is fully accredited by NABL (National Accreditation Board for Testing and Calibration Laboratories) and ISO 9001:2015 certified. Our radiology equipment also complies with AERB (Atomic Energy Regulatory Board) safety standards. These accreditations ensure that every Transcriptome Sequencing performed at our facility meets the highest national and international quality benchmarks for accuracy, safety, and reliability.
