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First of all, Gene expression profiling (RNA-Seq) is the state-of-the-art molecular technique that maps cellular gene expression and transcriptomic activity in real time. Essentially, Next-Generation Sequencing converts RNA into cDNA to quantify active gene transcription, detect oncogenic driver fusions, and identify splice variants with 99.9% precision. Consequently, oncologists and medical geneticists uncover therapeutic targets that DNA sequencing alone cannot reveal.
Furthermore, book your Gene Expression Profiling at Henotic Diagnostics for comprehensive diagnostic precision. In addition, our accredited genomic laboratory operates 24/7 with specialized sample collection logistics.
To begin with, Gene expression profiling provides a comprehensive snapshot of cellular gene expression by profiling messenger RNA (mRNA) and non-coding RNA species. At the same time, experts at Henotic Diagnostics perform high-depth cDNA library preparation and Next-Generation Sequencing to evaluate functional transcriptomic changes.
Furthermore, comfortable reception lounge ensuring a smooth, supportive sample registration process
What Does RNA Sequencing Evaluate?
Specifically, Gene expression profiling quantifies transcript abundance across thousands of genes to build differential expression profiles. Consequently, bioinformatic algorithms discover therapeutic oncogenic gene fusions (NTRK, RET, ALK, ROS1) and aberrant splicing isoforms. Furthermore, high-depth RNA-Seq measures non-coding RNA activity. As a result, physicians select highly effective targeted therapies. In fact, to review foundational transcriptomic concepts, consult the NIH NHGRI Transcriptome Fact Sheet.
In general, while genomic DNA sequencing reveals inherited mutations, Gene expression profiling (RNA-Seq) captures real-time functional gene activity. Essentially, total RNA is extracted, purified, depleted of ribosomal RNA, converted into cDNA, and sequenced on high-throughput NGS platforms. Therefore, bioinformatic software maps reads to quantify exact gene expression levels. Additionally, to read about technological advances, examine the Nature Reviews Genetics journal.
In addition, bioinformatic software maps gene fusion junctions, RNA expression heatmaps, and splice graphs
When Is RNA Sequencing Recommended?
For example, medical oncologists and hematologists order Gene expression profiling for advanced or refractory cancers to discover rare gene fusions. In particular, testing is recommended for lung adenocarcinoma, soft tissue sarcomas, pediatric tumors, and hematologic malignancies. Moreover, it is used in rare genetic disease research when DNA sequencing yields uninformative results. In addition, to review precision oncology standards, examine the NCI Precision Medicine in Cancer guide.
Moreover, expert clinical consultation translates RNA fusion data into targeted kinase inhibitor therapies
Clinical Advantage: RNA-Seq Fusion Calling vs. DNA Panel Limitations
Why RNA-Seq Identifies Fusions Hidden in Long Intronic Regions
Ideally, oncologists should order Gene expression profiling (RNA-Seq) because genomic DNA panels often miss gene fusions occurring across vast, repetitive intronic regions. In addition, Gene expression profiling directly captures expressed chimeric mRNA transcripts without intron interference. Indeed, to review global cancer diagnostic facts, consult the WHO Cancer & Diagnostics Fact Sheet.
RNA Sequencing Cost Guide
Clinical RNA Service
Approximate Cost (₹)
Targeted RNA Gene Fusion Panel
First, targeted oncology RNA fusion pricing is ₹32,000 – ₹42,000.
In addition, PaxGene / RNA-later kit delivery is complimentary.
Clinical Bioinformatic Report Consultation
Finally, expert consultation fee is ₹1,000 – ₹1,500.
Comparison: RNA Sequencing (RNA-Seq) vs. DNA Exome (WES)
On one hand, DNA Whole Exome Sequencing (WES) analyzes coding exon mutations, whereas Gene expression profiling (RNA-Seq) measures active gene expression and expressed fusion transcripts. Consequently, combining DNA WES with RNA-Seq provides complete diagnostic precision. In fact, review the PubMed Clinical Gene expression profiling Review.
Feature
RNA Sequencing (RNA-Seq)
DNA Whole Exome (WES)
Analyzed Molecule
First, dynamic expressed RNA (mRNA).
However, static genomic DNA coding exons.
Expression Quantification
Second, exact transcript expression levels.
In contrast, zero expression quantification capability.
Gene Fusion Detection
In addition, direct high-sensitivity fusion discovery.
Meanwhile, limited intronic fusion detection.
Clinical Utility
Finally, targeted oncology & functional variants.
Likewise, Mendelian germline & somatic SNVs.
Frequently Asked Questions
Is RNA Sequencing painful?▼
However, routine blood sample draw involves only a mild needle prick, while tissue biopsy samples are processed from archived blocks.
Do I need to fast before RNA Sequencing?▼
Because RNA expression profiling is independent of blood glucose, fasting is unnecessary.
What sample is required for RNA Sequencing?▼
Generally, peripheral blood in PaxGene tubes or fresh-frozen / FFPE tissue blocks are accepted.
How long until I receive diagnostic RNA Sequencing results?▼
Fortunately, detailed clinical bioinformatic RNA-Seq reports are delivered within 10 to 14 business days.
What is the cost of RNA Sequencing?▼
Overall, high-precision Gene expression profiling ranges from ₹32,000 to ₹55,000 all-inclusive.
Quick Appointment Booking
Schedule your Gene expression profiling with accredited genomic experts.
MBBS, MD (Genomics Analysis) · 15+ Years Clinical Experience
Furthermore, your Gene expression profiling data is interpreted by accredited molecular geneticists and bioinformaticians. Consequently, comprehensive reports empower oncologists with actionable RNA expression and fusion target insights.
Real feedback from patients who completed RNA Sequencing with us.
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“RNA Sequencing discovered an ALK fusion transcript in my lung biopsy that standard PCR missed. Furthermore, targeted therapy began immediately with remarkable success!”
– Alok D.
Verified Patient Review
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“Fast PaxGene blood tube sample pickup and extremely clear report charts. In addition, the genetic counselor guided our oncologist through the report.”
– Sunita M.
Verified Patient Review
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“State-of-the-art NABL accredited RNA sequencing precision. Henotic Diagnostics is our trusted referral lab for transcriptomic oncology.”
You can book your Rna Sequencing appointment at our Navi Mumbai center through multiple convenient channels: call us directly at 088793 27184, send a WhatsApp message for instant booking, or use the online booking form on our website. Walk-in appointments are also welcome based on slot availability. We recommend advance booking to ensure zero wait times.
Yes, Henotic Diagnostics Navi Mumbai is empanelled with all major insurance companies and TPAs (Third Party Administrators) including Star Health, ICICI Lombard, New India Assurance, HDFC Ergo, Max Bupa, Bajaj Allianz, and many more. We offer cashless processing for Rna Sequencing where applicable. Please carry your insurance card and a valid ID for seamless processing.
At Henotic Diagnostics Navi Mumbai, most Rna Sequencing reports are delivered within 2-6 hours for routine tests. Critical and urgent reports are expedited on a priority basis. All reports are delivered digitally via WhatsApp, email, and our secure online patient portal. Hard copies are also available at the center upon request. You will receive an SMS/WhatsApp notification the moment your report is ready.
Henotic Diagnostics Navi Mumbai operates 24 hours a day, 7 days a week, including Sundays and public holidays. This means you can schedule your Rna Sequencing at a time that is most convenient for you — early morning, late evening, or even overnight for emergency requirements. Our radiology and pathology departments maintain round-the-clock availability.
Yes, Henotic Diagnostics Navi Mumbai is fully accredited by NABL (National Accreditation Board for Testing and Calibration Laboratories) and ISO 9001:2015 certified. Our radiology equipment also complies with AERB (Atomic Energy Regulatory Board) safety standards. These accreditations ensure that every Rna Sequencing performed at our facility meets the highest national and international quality benchmarks for accuracy, safety, and reliability.
